Kamagra (Generic
Viagra) [sildenafil citrate], manufactured by Ajanta
Pharma, Ltd, this
drug is the first cyclic guanosine monophosphate [cGMP] specific
phosphodiesterase type 5 enzyme inhibitor. This enzyme helps in regulating
the blood circulation in the penile tissue. This leads to better penile
erection.
Kamagra (Generic
Viagra) is primarily indicated in the treatment of impotence [erectile
dysfunction]
The compound sildenafil was synthesized in Pfizer’s
research lab in Kent, England. Believe it or not, sildenafil
was actually being studied for the treatment of hypertension and angina
pectoris. Angina pectoris, or chest pain, caused by an insufficient supply of
oxygen and decreased blood flow to the heart muscle. Angina is frequently the
first sign of ischemic heart disease. However, during the phase 1 clinical
trials, it was found that instead of having a remarkable action on angina, this
drug was very effective in inducing penile erections, the main pathology behind
erectile dysfunction.
The drug was patented in 1996,
approved for use in erectile dysfunction by the Food and Drug Administration on
March 27, 1998, becoming the first oral treatment approved to treat erectile
dysfunction in the United States
Needless to say, this drug has become a household hit.
Erectile dysfunction:
Erectile dysfunction (ED) is defined as the inability of a
man to achieve or maintain an erection sufficient for his sexual needs or the
needs of his partner
Erection of the penis during
coitus or otherwise is a result of increase in the blood flow of the arteries
of the penis and simultaneous relaxation of the smooth muscle of corpora
cavernosum. This whole process is due to the release of nitric oxide (NO) from
nerve terminals and endothelial cells, which stimulates the synthesis of cGMP
in smooth muscle cells. Cyclic GMP in turn, relaxes smooth muscle and resulting
in an increase in the blood flow to the corpus cavernosum.
In erectile dysfunction, enough blood does not
flow in the arteries of the penis to cause a sufficient erection.
.An organic cause
can be found out in about 50% of the cases of erectile dysfunction; the rest
are either psychogenic in origin or are due to a psychiatric illness such as
depression which requires appropriate drug treatment. Systemic diseases like
chronic liver or kidney diseases and drug addiction are important causes and
should be looked for. In case of any psychogenic problem, even the partner
should be actively involved in the counseling therapy
The physiologic mechanism of erection of the penis
involves release of nitric oxide (NO) in the corpus cavernosum of the penile
tissue during sexual stimulation. Nitric oxide then activates the enzyme guanylate
cyclase, which results in increased levels of cyclic guanosine
monophosphate (cGMP), producing smooth muscle relaxation in the corpus
cavernosum and allowing inflow of blood. Kamagra (Generic
Viagra) [sildenafil citrate] has no direct relaxant effect on isolated
human corpus cavernosum, but enhances the effect of nitric oxide (NO) by
inhibiting phosphodiesterase type 5 (PDE5), which is responsible for
degradation of cGMP in the corpus cavernosum. When sexual stimulation causes
local release of nitric oxide, inhibition of PDE5 by sildenafil causes
increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle
relaxation and inflow of blood to the corpus cavernosum. Sildenafil at
recommended doses has no effect in the absence of sexual stimulation.
There are many types of PDE, each having varied function.
The plus point of Kamagra (Generic Viagra) [sildenafil citrate] is that
it is PDE 5 selective, though it can also act on the other types of PDE. In
fact higher doses or plasma levels of the drug is thought to be associated with
defects in color vision due to its action on PDE 6.
Kamagra (Generic Viagra) [sildenafil citrate] has a
4,000-fold selectivity for PDE5 versus PDE3, which is concerned with cardiac
contractility.
Indications:
Erectile dysfunction. This is the
main indication whereas for the indications given below, sildenafil is not in
the first line treatment regimen.
pulmonary arterial hypertension
prevention of high altitude
pulmonary edema associated with altitude sickness
Relieving female sexual
dysfunction. Several studies have indicated the drug may be effective in
improving libido and arousal in women taking selective serotonin uptake
inhibitors (SSRIs)
Treatment of infertility. Women
who have had repeated failures with in vitro fertilization (IVF) due to poor
development of the endometrium [tissue that lines the uterus] may benefit from
treatment with vaginal suppositories containing sildenafil.
Esophageal motility dysfunction
(achalasia), since it can enhance nitric oxide production.
Contraindications:
- patients on nitric oxide drugs since sildenafil
potentiate the hypotensive effects of nitrates, and its administration to
patients who are using organic nitrates, either regularly and/or
intermittently, in any form is therefore contraindicated.
- There is a degree of cardiac risk
associated with sexual activity, especially in elderly people above the age of
60 years. There is increase incidence of mortality and morbidity with KAMAGRA
(GENERIC VIAGRA) [sildenafil]
- Severe hepatic
impairment (decreased liver function)
The most commonly reported side effects of KAMAGRA
(GENERIC VIAGRA) are headache, flushing of the face, upset stomach, and nasal
congestion.
Other less common side effects include, but are not
limited to:
vision
problems, including sensitivity to light, blurred vision, and a color
tinge to vision
urinary
tract infection
diarrhea
dizziness
rash
Dosage:
Administered in the dose of 50 mg one hour before the
intended sexual activity. Based on effectiveness and toleration, it can be
increased to 100 mg or decreased to 25 mg.
Advancements in the field of science have a
tremendous effect in the lifestyle of people around the world. The things which
we were only conceiving in our minds a long time ago came into reality after
years of research and testing of the greatest minds of every century. The
pursuit for the elixir of life has become a race for most developed countries so
a lot of them are investing a lot of money, time and effort just to bring
quality life in every household around the globe, most especially to those who
can afford.
With these evident realities at hand, it is
undoubtedly a fact that aside from the prolonging of life span, production of
goods which are luxurious and would give immediate satisfaction is also being
held as a primary consideration. In medical science, one such thing that has
brought so much change in the lifestyle of people is the manufacture of Viagra,
Kamagra a
drug that has been popular among people of all ages and races for adding more
color to one of the basic needs of humanity---sex.
BRIEF HISTORY
It is safe to remember that Viagra is not for
everybody. Originally, Viagra was developed by Pfizer as a drug to help
men who were suffering from chest pain. However, sildenafil citrate, the active
ingredient of Viagra, as a heart medication did not show progress of attaining
its purpose and studies were stopped in 1992. Yet, based on published
information about some properties contained in sildenafil citrate, Pfizer
researchers began to look at it as a treatment for erectile dysfunction. Erectile
dysfunction can also be termed as impotence or the difficulty to have an
erection or maintaining it among males. Re-evaluation for its effect on the
ability of men with ED to engage in sexual activity, and the ability to achieve
and maintain erection sufficient for satisfactory sexual activity was taken.
Later,
the clinical trials conducted by the researchers found Viagra to be so
effective that the FDA approved it only six months after submission, and
without consulting an advisory committee of outside experts because there were
no troubling questions and no significant side effects.In furtherance to its primary uses, Viagra is being tested
against pulmonary hypertension in children and infertility in women.
HOW IT
WORKS
Basically Viagra’s appearance is
bluish, diamond-shaped tablets with 25mg, 50mg, or 100mg strengths embossed on
one side, denoting tablet strength. It works by dilating blood vessels
throughout the body, allowing blood to flow more readily to the heart, lungs
and other organs. Moreover, Generic Viagra relaxes smooth muscle contractions
in the penis. Around 70 percent of men using it reported some improvement in
achieving and maintaining an erection. Effects normally begin within 30 minutes
and last about 4 hours.
Since
Viagra is only for those who have erectile dysfunctions, the drug must be taken orally once a day, one hour before
the sexual activity. Viagra is not meant to be taken regularly for a prolonged
period. Just take it when you need it.
An important thing to remember
also is, you should not take Viagra if you are using nitrate drugs to control
angina pain because the combination of the nitrate drugs and Viagra can lower
your blood pressure dangerously putting your life in danger. The combinations
of drugs are life-threatening for you. If it gives you an allergic reaction, do
not use it again. Also, if you have severe heart problems where sexual activity
can be a danger to your life, do not take Viagra.
AFTER EFFECTS
Side
effects of using Viagra include headache, flushed skin, and anxiety. Its serious
risks can include distorted vision and priapism -- a painful, prolonged erection
that may require medical intervention. Historically, 69 deaths were linked to
Viagra during its first three months on the market so the U.S. Food and Drug
Administration issued a warning against using it with amyl nitrate
("poppers"), nitroglycerin, and nitrous oxide since each dilates
blood vessels, thus, a dangerous drop in blood pressure can result, leading to
possible heart attack or stroke.
ADDICTIVE?
Probably yes. Firstly, men who take Viagra to
obtain even greater pleasure from their sex life become so much used to the
drug that they find their love life uninteresting without the use of Viagra, as
compared to earlier. Secondly, to some men, the effect of Viagra may decrease
with time hence these men are less likely to have a non Viagra erection as
compared to earlier when they did not take Viagra. Moreover, some men with no
performance problems except psychologically may take even far larger doses of
the drug to satisfy their own perception of a satisfactory sexual performance.
CONCLUSION
With the facts given, the question now is, “Is it
for you?” Think it over. Never rush.
Erectile dysfunction, or the inability to achieve or maintain an erection well enough for satisfying sexual activity, can be caused by numerous factors, both physical and psychological. Some of the causes include nerve damage, reduced blood flow to the penis, side effects of medications, neurological conditions, trauma, depression, anxiety, and stress.
Viagra, which is the same thing as the generic drug sildenafil, was the first drug introduced for the treatment of erectile dysfunction, or ED. Introduced in 1998, sildenafil has been used by millions of men over the past decade. It is available in dosages of 25, 50, or 100 mg. This article will discuss how sildenafil works, what its side effects are, and who should not take it.
How sildenafil works Sildenafil is in a class of drugs known as phosphodiesterase type 5 inhibitors, or PDE5 inhibitors. For proper arterial blood flow to the penis, a substance called cGMP must be present in a large enough concentration so that it can work to relax the blood vessels, dilating them so that blood flow to the penis is increased. If PDE5 is blocked, then less cGMP is destroyed, allowing it to remain at high enough concentrations to allow adequate blood flow to the penis. Other drugs of this type include Levitra and Cialis.
Sildenafil should be taken one-half to one hour before any planned sexual activity. Its effects generally last for about four hours.
Side effects of sildenafil : Sildenafil, like every drug, has side effects. Most of them are not pronounced enough to cause you to stop taking the drug. Common side effects include headache, stomach ache, stuffy nose, diarrhea, blurred vision, or visual changes that make things appear to have a blue tint. Normally, these side effects go away after a few hours.
There are some side effects that can be serious, however, and that should be reported to your doctor. Serious side effects include a sudden drastic drop in blood pressure, heart arrhythmia (irregular heartbeat), increased pressure in the eye, and sudden hearing loss. Priapism, an erection that lasts longer than four hours, is another serious side effect. Any of these side effects should be reported to your doctor immediately.
Who should not take sildenafil? As of November 1998, 130 deaths had been associated with the use of Viagra in the U.S. Sixteen of the men who died had also taken a nitrate.
Men who are not generally healthy enough for sexual activity should not take sildenafil. Soon after sildenafil was introduced in 1998, a number of deaths were associated with it. Many of the men who died had also taken a nitrate containing drug. Men who take drugs containing nitrates should not take it either. Nitrate containing drugs include nitroglycerin, isosorbide mononitrate and isosorbide dinitrate. The possible effects of nitrates combined with the effects of sildenafil include dangerous drop in blood pressure, stroke, or heart attack. Men who take alpha blockers and beta blockers should discuss with their doctor whether sildenafil is an appropriate drug for them.
Certainly
the most famous drug against erectile dysfunction (ED) on the market is the
Viagra—and it costs a fortune to buy. For people with ED, who want an effective
treatment without having to invest much, Kamagra is the
solution. Kamagra
is a generic version of drugs for treatment of ED and is designed to
immediately help any man with ED once it is prescribed. The purpose of the drug
is to increase blood flow to the penis so that the latter hardens easily when
the person is sexually aroused. The person will therefore have no difficulty
obtaining and keeping the erection during sex.
Some of the potential side
effects of the drug include flushing, running nose, headaches and eyesight
impairment. This includes seeing everything with a bluish tinge. All side
effects should be discussed with your doctor so that he can determine any
change in the treatment. Headaches are fairly common but vision impairments are
very rare among the mentioned adverse effects.
Since Kamagra
can only be given with the consent of a doctor, the latter will need to take a
considerable part in your treatment. You therefore need to discuss your
condition extensively with him. The doctor also needs complete access to your
medical history in order to allow him to ascertain whether Kamagra
is appropriate for you. For example, if you are already under certain types of
medication that contain nitrates (e.g. Mononitrate, Vasonitrate, and Angicor), Kamagra
might not be suitable for you. Kamagra
pills are taken when needed. They should be taken about an hour before sexual
intercourse. Its effects typically remain for about 30 minutes, although it
could go on for four hours. Sexual arousal is a crucial part for the
functioning of Kamagra. Longer erections, lasting over four
hours, can lead to long term damage. It is therefore necessary to inform your
doctor if you are experiencing this.
One important advice: never
purchase Kamagra, or any other drug for that matter, over
the Internet. Kamagra requires medical supervision. Taking
it without the discerning eye of a doctor could lead to more difficulties than
it would solve.
Since Kamagra
is generic medicine, it is considerably less than the brand name drug
Viagra. Thus, treatment of erectile
dysfunction would not be a strain on your finances. It is however to take all
the necessary precautions when taking the drug. It is also important to
disclose all relevant information to your doctor especially about past
treatments or medical operations that you may have undergone. As soon as the
doctor gives you permission to use Kamagra, it can be taken
about an hour before sex. It need not be taken on a regular basis. Afterwards
it is only fun and games…
